Notice: Get a jump on 2015 — Pay your 2015 ASA membership dues now!




January 23 - 25 2015, 12:00 AM - 12:00 AM


February 07 - 08 2015, 12:00 AM - 12:00 AM

ASA Certificate in Business Administration 2015

June 26 - 28 2015, 12:00 AM - 12:00 AM

Annual Perioperative Surgical Home Summit



December 18, 2014

0.9 Percent Sodium Chloride Injection USP in 100 mL MINI-BAG PLUS Container by Baxter: Recall - Particulate Matter


FDA MedWatch Recall - Particulate Matter

November 21, 2014

FDA MedWatch - Respironics California, Esprit V1000 and V200 Ventilators: Class I Recall - Power Failure May Occur


FDA MedWatch Respironics California Esprit V1000 and V200 Ventilators Class I Recall

November 21, 2014

FDA MedWatch - Highly Concentrated Potassium Chloride Injection, 10 mEq per 100 mL by Baxter: Recall - Mislabeled


Highly Concentrated Potassium Chloride Injection 10 mEq per 100 mL by Baxter Recall Mislabeled



Add this product to your shopping cart

Self-Education and Evaluation (SEE) Program

SKU: 30701-14CE

... Read more »

Single Copies, Member Price: $360

Gene Variation Found to Help Predict Surgical Outcomes of Coronary Artery Bypass Graft Surgery Patients

Chicago — (March 24, 2010) 

A study with far-reaching implications for patients undergoing coronary artery bypass graft (CABG) surgery has identified human genetic variants that could help doctors predict the potential for certain patients to suffer poor heart function.

Amanda A. Fox, M.D., and her co-investigators from the Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital and the Division of Cardiovascular Anesthesiology at the Texas Heart Institute, identified variants in two sets of genes that, when added into a clinical model for predicting heart function, offer significant improvement in the ability to anticipate heart problems after surgery.

“The gene variants we studied have been associated with cardiovascular disease states such as hypertension, stroke and myocardial infarction,” said Dr. Fox. “However, to date, the association between these genes and development of heart failure after cardiac surgery with cardiopulmonary bypass has not been examined.”

Dr. Fox’s research focused on a group of protein hormones called natriuretic peptides, which are secreted by heart muscle cells. These natriuretic peptides help to stabilize the body by controlling such things as the amount of water, sodium, potassium and fats in the bloodstream. 

Dr. Fox hypothesized that gene variants in natriuretic peptides could independently predict which patients might have poor heart muscle function after heart surgery. Such knowledge would lead to a better understanding of molecular mechanisms underlying postoperative heart failure.

In a companion editorial to the study, John H. Eisenach, M.D., stated that Dr. Fox’s research could be an important next step in clinical genomics.

“The magnitude of this modern collaborative clinical trial is remarkable,” said Dr. Eisenach, Mayo Clinic, Rochester. “This study has potential implications for the prediction of postoperative morbidity, development of disease prevention strategies and personalized pharmacological interventions that pertain to the natriuretic pathway.”

Dr. Fox said that future research needs to broaden the scope of genetic associations in other cardiac surgical patients. Her study included 697 Caucasian subjects.

“The gene variants we studied differ in frequency between people depending upon ethnic backgrounds, requiring that analysis of these variants be stratified by race,” she said.

Dr. Eisenach sees studies such as the one by Dr. Fox and her group as signaling new directions in clinical genomics, a formative field in anesthesiology research.

“The mind-bending speed of genomic technology and discovery has outpaced genomic education in medical school and anesthesiology residency,” he said. “Eventually, education in genomics will be essential for practitioners to translate genomic discoveries into clinical practice.”


Founded in 1905, the American Society of Anesthesiologists (ASA) is an educational, research and scientific society with more than 52,000 members organized to raise and maintain the standards of the medical practice of anesthesiology. ASA is committed to ensuring physician anesthesiologists evaluate and supervise the medical care of patients before, during and after surgery to provide the highest quality and safest care every patient deserves.

For more information on the field of anesthesiology, visit the American Society of Anesthesiologists online at . To learn more about the role physician anesthesiologists play in ensuring patient safety, visit Like ASA on Facebook , follow ASALifeline on Twitter and follow ASA on LinkedIn .



American Society of Anesthesiologists