Notice: Get a jump on 2015 — Pay your 2015 ASA membership dues now!




January 23 - 25 2015, 12:00 AM - 12:00 AM


February 07 - 08 2015, 12:00 AM - 12:00 AM

ASA Certificate in Business Administration 2015

June 26 - 28 2015, 12:00 AM - 12:00 AM

Annual Perioperative Surgical Home Summit



December 18, 2014

0.9 Percent Sodium Chloride Injection USP in 100 mL MINI-BAG PLUS Container by Baxter: Recall - Particulate Matter


FDA MedWatch Recall - Particulate Matter

November 21, 2014

FDA MedWatch - Respironics California, Esprit V1000 and V200 Ventilators: Class I Recall - Power Failure May Occur


FDA MedWatch Respironics California Esprit V1000 and V200 Ventilators Class I Recall

November 21, 2014

FDA MedWatch - Highly Concentrated Potassium Chloride Injection, 10 mEq per 100 mL by Baxter: Recall - Mislabeled


Highly Concentrated Potassium Chloride Injection 10 mEq per 100 mL by Baxter Recall Mislabeled



Add this product to your shopping cart

Self-Education and Evaluation (SEE) Program

SKU: 30701-14CE

... Read more »

Single Copies, Member Price: $360

Study Finds Genetic Variation That Could Help Predict Mortality in Patients Suffering Sepsis

Chicago — (December 19, 2012) 

A study in the January 2013 issue of Anesthesiology offers evidence that variations in what is called the NFκB gene could play an important role in helping to determine the survival rate of patients who acquire sepsis, a condition in which the body is overwhelmed by infection, and which is the leading cause of death in hospitals.

“Wide variability exists regarding the outcome of patients with severe sepsis, and some of the variability regarding the risk of dying could be caused by genetic variations,” said lead study author Michael Adamzik, M.D., Associate Professor, Department of Anesthesiology and Intensive Care Medicine, University Duisberg-Essen, Essen, Germany. “Our study unravels the molecular mechanism by which a common genetic variation in the regulation region of the NFκB gene may amplify and perpetuate inflammation and infection due to sepsis.”

Using blood from human subjects, Dr. Adamzik and his research team found that patients with a specific genetic variation (58 percent of the study group) showed, after infection, a two-fold increase of a subunit protein called NFκB-1 and more inflammation compared to patients with other genotypes.

The NFκB genetic pathway is believed to be responsible for amplifying inflammation that takes place in sepsis. Dr. Adamzik’s study seems to indicate that the protein NFκB-1, specifically, could affect the key mechanism of sepsis and possibly influence patient survival rates.

“This genetic variation turned out to represent both an important and independent predictor of mortality in our patients,” said Simon Schäfer, M.D., Research Assistant, Department of Anesthesiology and Intensive Care Medicine, University Duisberg-Essen. “Patients with one genetic variant were associated with an almost two-fold greater risk for death during sepsis. Our study showed for the first time that this genetic variation markedly increases inflammation and influences the risk of dying from sepsis.”

Dr. Adamzik stated that future studies should work to unravel whether anti-inflammatory sepsis treatment should be adjusted in patients according to their genotype.

For more information, visit the Anesthesiology website at


Founded in 1905, the American Society of Anesthesiologists (ASA) is an educational, research and scientific society with more than 52,000 members organized to raise and maintain the standards of the medical practice of anesthesiology. ASA is committed to ensuring physician anesthesiologists evaluate and supervise the medical care of patients before, during and after surgery to provide the highest quality and safest care every patient deserves.

For more information on the field of anesthesiology, visit the American Society of Anesthesiologists online at . To learn more about the role physician anesthesiologists play in ensuring patient safety, visit Like ASA on Facebook , follow ASALifeline on Twitter and follow ASA on LinkedIn .



American Society of Anesthesiologists