John W. Severinghaus Lecture on Translational Science

SPE22 John W. Severinghaus Lecture on Translational Science: Basic Science to Clinical Practice: The Tale of Long-Acting Opioids
Tuesday, October 14, 2014, 10:30 – 11:30 a.m.
Evan D. Kharasch, M.D., Ph.D.

Opioids such as methadone provide long-lasting relief of acute, perioperative, chronic and cancer pain, and are pivotal to anesthesia practice. Yet with the increase in methadone use, there has been a terrifying increase in untoward events. Only recently has there been a better understanding of methadone pharmacology, including pharmacokinetics, pharmacodynamics and pharmacogenetics. This lecture tells the story of how these clinical problems were studied in the basic science laboratory, how the insights gained were then verified in clinical trials, and how this new knowledge can guide clinical practice, improve clinical outcome and guide practice.

Dr. Kharasch is Vice Chancellor for Research, Russell D. and Mary B. Shelden Professor of Anesthesiology; Director, Division of Clinical and Translational Research, Department of Anesthesiology, and Professor of Biochemistry and Molecular Biophysics, Washington University in St. Louis.